In England, compulsory vaccination against smallpox was first
introduced in 1852, yet in the period 1857 to 1859, a smallpox epidemic killed 14,244 people.

In 1863 to 1865, a second epidemic claimed 20,059 lives.

In 1867, a more stringent compulsory vaccination law was passed and
those who evaded vaccination were prosecuted. After an intensive tour
year effort to vaccinate the entire population between the ages of 2 to 50, the Chief Medical Officer of England announced in May 1871 that
97.5% had been vaccinated.

In the following year, 1872, England experienced its worst ever smallpox epidemic which claimed 44,840 lives.

Between 1871-1880, during the period of compulsory vaccination, the
death rate from smallpox leapt from 28 to 46 per 100,000 population.

Writing in the British Medical Journal (21/1/1928 p116) Dr L Parry
questions the vaccination statistics which revealed a higher death rate amongst the vaccinated than the unvaccinated and asks: "How is it that smallpox is five times as likely to be fatal in the vaccinated as in the unvaccinated?

"How is it that in some of our best vaccinated towns - for example,
Bombay and Calcutta - smallpox is rife, whilst in some of our worst
vaccinated towns, such as Leicester, it is almost unknown?

"How is it that something like 80 per cent of the cases admitted Into the Metropolitan Asylums Board smallpox hospitals have been vaccinated, whilst only 20 per cent have not been vaccinated?

"How is it that in Germany, the best vaccinated country in the world,
there are more deaths in proportion to the population than In England - for example, in 1919, 28 deaths in England, 707 In Germany; In 1920, 30 deaths In England, 354 In Germany In 1919

There were 5,012 cases of smallpox with 707 deaths; in England In 1925, there were 5,363 cases of smallpox with 6 deaths.